Application

Results of immunohistochemistry in the dorsal root ganglion have been described by Chen. C., et al., Neurochemical Research (1996) 21(7):809-814..

Research CategoryNeuroscience

Research Sub CategoryNeurochemistry & Neurotrophins

Tyrosine Kinase Receptor C is an antibody targeting the Tyrosine Kinase Receptor C protein, validated for use in IHC.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The mammalian Trk family of receptor tyrosine kinases consists of three principle transmembrane proteins. The receptors can be activated by one or more of four neurotrophins - NGF, BDNF, NT3 and NT4. Each of the four members of the TrkC family, expressed by alternative splicing, serves as a receptor for NT-3, with some evidence for endogenous activation also by NGF. These neurotrophins regulate biological responses such as cell survival, proliferation and differentiation in normal and neoplastic neuronal cells primarily, but several other cell types have been shown to express the TrkC receptor. The receptor has also been demonstrated on many tumors of neuronal origin.

Immunogen

Extracellular domain of the recombinant human receptor expressed in mammalian cells.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

Lyophilized. Reconstitute with 50 µL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative.

Serum

Specificity

trkC [Neurotrophin-3 growth factor receptor; tyrosine kinase receptor C]. All four forms of the TrkC receptor are expected to be detected by this antibody. The immunogen sequence was chosen to avoid cross reactivity with trkA or trkB.

Storage and Stability

Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability.